Resource Page

AHCC® Clinical Evidence

AHCC® Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections. Smith JA, Gaikwad AA, Mathew L, Rech B, Faro JP, Lucci JA 3rd, Bai Y, Olsen RJ, Byrd TT. (PubMed)

AHCC®, a Standardized Extract of Cultured Lentinula Edodes Mycelia, Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer. Park HJ, Boo S, Park I, Shin MS, Takahashi T, Takanari J, Homma K, Kang I. (PubMed

The Effects of AHCC®, a Standardized Extract of Cultured Lentinura edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies. Shin MS, Park HJ, Maeda T, Nishioka H, Fujii H, Kang I. (PubMed)

From Bench to Bedside: Evaluation of AHCC Supplementation to Modulate the Host Immunity to Clear High-Risk Human Papillomavirus Infections. Smith JA, Mathew L, Gaikwad A, Rech B, Burney MN, Faro JP, Lucci JA 3rd, Bai Y, Olsen RJ, Byrd TT. (PubMed

Effects of AHCC® on Immune and Stress Responses in Healthy Individuals. Takanari J, Sato A, Waki H, Miyazaki S, Uebaba K, Hisajima T. (PubMed

Potential Role for Active Hexose Correlated Compound (AHCC) in Treatment of Recurrent Respiratory Papillomatosis. Gau VL, Benninger MS. (PubMed

Could Active Hexose Correlated Compound (AHCC) Currently Be an Appropriate Choice to Clear Human Papillomavirus Infection? Farasatinasab M, Nassiri S. (PubMed

Active Hexose Correlated Compound (AHCC) Inhibits the Proliferation of Ovarian Cancer Cells by Suppressing Signal Transducer and Activator of Transcription 3 (STAT3) Activation. Choi JY, Lee S, Yun SM, Suh DH, Kim K, No JH, Jeong EH, Kim YB. (PubMed

AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation. Olamigoke L, Mansoor E, Mann V, Ellis I, Okoro E, Wakame K, Fuji H, Kulkarni A, Francoise Doursout M, Sundaresan A. (PubMed

Effect of Active Hexose Correlated Compound (AHCC) in alcohol-induced liver enzyme elevation. Kim H, Kim JH, Im JA. (PubMed

An evidence-based systematic review of active hexose correlated compound (AHCC) by the Natural Standard Research Collaboration. Ulbricht C, Brigham A, Bryan JK, Catapang M, Chowdary D, Costa D, Culwell S, D’Auria D, Giese N, Iovin R, Isaac R, Juturu V, Liu A, Mintzer M, Rusie E, Shaffer M, Windsor RC. (PubMed

Active Hexose Correlated Compound (AHCC) promotes an intestinal immune response in BALB/c mice and in primary intestinal epithelial cell culture involving toll-like receptors TLR-2 and TLR-4. Mallet JF, Graham É, Ritz BW, Homma K, Matar C. (PubMed

Evaluation of Active Hexose Correlated Compound (AHCC) in Combination With Anticancer Hormones in Orthotopic Breast Cancer Models. Mathew L, Gaikwad A, Gonzalez A, Nugent EK, Smith JA. (PubMed

Therapeutic effect of Active Hexose-Correlated Compound (AHCC) combined with CpG-ODN (oligodeoxynucleotide) in B16 melanoma murine model. Ignacio RM, Kim CS, Kim YD, Lee HM, Qi XF, Kim SK. (PubMed

Genotoxicity and subchronic toxicity evaluation of Active Hexose Correlated Compound (AHCC). Fujii H, Nishioka N, Simon RR, Kaur R, Lynch B, Roberts A. (PubMed

Activation of NF-E2 p45-related factor-2 transcription and inhibition of intestinal tumor development by AHCC, a standardized extract of cultured Lentinula edodes mycelia. Takahashi M, Fujii G, Hamoya T, Kurokawa Y, Matsuzawa Y, Miki K, Komiya M, Narita T, Mutoh M. (PubMed

Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longumAHCC® and Azithromycin in Healthy Individuals. Chowdhury AH, Cámara M, Verma C, Eremin O, Kulkarni AD, Lobo DN. (PubMed

Alleviating Effect of Active Hexose Correlated Compound (AHCC) on Chemotherapy-Related Adverse Events in Patients with Unresectable Pancreatic Ductal Adenocarcinoma. Yanagimoto H, Satoi S, Yamamoto T, Hirooka S, Yamaki S, Kotsuka M, Ryota H, Michiura T, Inoue K, Matsui Y, Tsuta K, Kon M. (PubMed

The nutritional supplement Active Hexose Correlated Compound (AHCC) has direct immunomodulatory actions on intestinal epithelial cells and macrophages involving TLR/MyD88 and NF-κB/MAPK activation. Daddaoua A, Martínez-Plata E, Ortega-González M, Ocón B, Aranda CJ, Zarzuelo A, Suárez MD, de Medina FS, Martínez-Augustin O. (PubMed

The Effects of Active Hexose Correlated Compound (AHCC) on Levels of CD4+ and CD8+ in Patients with Epithelial Ovarian Cancer or Peritoneal Cancer Receiving Platinum Based Chemotherapy. Suknikhom W, Lertkhachonsuk R, Manchana T. (PubMed

Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled trial. Terakawa N, Matsui Y, Satoi S, Yanagimoto H, Takahashi K, Yamamoto T, Yamao J, Takai S, Kwon AH, Kamiyama Y. (PubMed

MicroRNA signature in the chemoprevention of functionally-enriched stem and progenitor pools (FESPP) by Active Hexose Correlated Compound (AHCC). Graham ÉA, Mallet JF, Jambi M, Nishioka H, Homma K, Matar C. (PubMed

Increased Efficacy of Oral Fixed-Dose Combination of Amphotericin B and AHCC® Natural Adjuvant against Aspergillosis. Pérez-Cantero A, Serrano DR, Navarro-Rodríguez P, Schätzlein AG, Uchegbu IF, Torrado JJ, Capilla J. (PubMed

Prognostic improvement of patients with advanced liver cancer after active hexose correlated compound (AHCC) treatment. Cowawintaweewat S, Manoromana S, Sriplung H, Khuhaprema T, Tongtawe P, Tapchaisri P, Chaicumpa W. (PubMed

A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. Spierings EL, Fujii H, Sun B, Walshe T. (PubMed

Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC. Haidari M, Zhang W, Wakame K. (PubMed

Possible therapeutic role of a highly standardized mixture of active compounds derived from cultured Lentinula edodes mycelia (AHCC) in patients infected with 2019 novel coronavirus. Di Pierro F, Bertuccioli A, Cavecchia I. (PubMed

Reduction of adverse effects by a mushroom product, active hexose correlated compound (AHCC) in patients with advanced cancer during chemotherapy–the significance of the levels of HHV-6 DNA in saliva as a surrogate biomarker during chemotherapy. Ito T, Urushima H, Sakaue M, Yukawa S, Honda H, Hirai K, Igura T, Hayashi N, Maeda K, Kitagawa T, Kondo K. (PubMed

A standardized extract of cultured Lentinula edodes mycelia downregulates cortactin in gemcitabine-resistant pancreatic cancer cells. Islam S, Kitagawa T, Baron B, Kuhara K, Nagayasu H, Kobayashi M, Chiba I, Kuramitsu Y. (PubMed

A Standardized Extract of Lentinula edodes Cultured Mycelium Inhibits Pseudomonas aeruginosa Infectivity Mechanisms. Tena-Garitaonaindia M, Ceacero-Heras D, Montoro MDMM, de Medina FS, Martínez-Augustin O, Daddaoua A. (PubMed

Preventing Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy With Active Hexose-correlated Compound Derived From Lentinula edodes Mycelia. Kamiyama T, Orimo T, Wakayama K, Kakisaka T, Shimada S, Nagatsu A, Asahi Y, Aiyama T, Kamachi H, Taketomi A. (PubMed

Active hexose-correlated compound enhances extrinsic-pathway-mediated apoptosis of Acute Myeloid Leukemic cells. Fatehchand K, Santhanam R, Shen B, Erickson EL, Gautam S, Elavazhagan S, Mo X, Belay T, Tridandapani S, Butchar JP. (PubMed

Nutritional impact of active hexose-correlated compound for patients with resectable or borderline-resectable pancreatic cancer treated with neoadjuvant therapy. Hashimoto D, Satoi S, Yamamoto T, Yamaki S, Ishida M, Ryota H, Sakaguchi T, Hirooka S, Inoue K, Sekimoto M. (PubMed

Active hexose correlated compound exerts therapeutic effects in lymphocyte driven colitis. Mascaraque C, Suárez MD, Zarzuelo A, Sánchez de Medina F, Martínez-Augustin O. (PubMed

Efficacy of active hexose correlated compound on survival of patients with resectable/borderline resectable pancreatic cancer: a study protocol for a double-blind randomized phase II study. Hashimoto D, Satoi S, Ishikawa H, Kodera Y, Kamei K, Hirano S, Fujii T, Uemura K, Tsuchida A, Yamada S, Yamamoto T, Hirota K, Sekimoto M. (PubMed

Active hexose-correlated compound down-regulates sex-determining region Y-box 2 of pancreatic cancer cells. Nawata J, Kuramitsu Y, Wang Y, Kitagawa T, Tokuda K, Baron B, Akada J, Suenaga S, Kaino S, Maehara S, Maehara Y, Sakaida I, Nakamura K. (PubMed

Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Roman BE, Beli E, Duriancik DM, Gardner EM. (PubMed

Adenosine, a hepato-protective component in active hexose correlated compound: its identification and iNOS suppression mechanism. Tanaka Y, Ohashi S, Ohtsuki A, Kiyono T, Park EY, Nakamura Y, Sato K, Oishi M, Miki H, Tokuhara K, Matsui K, Kaibori M, Nishizawa M, Okumura T, Kwon AH. (PubMed

CUB Domain-containing Protein 1 (CDCP1) Is Down-regulated by Active Hexose-correlated Compound in Human Pancreatic Cancer Cells. Kuhara K, Tokuda K, Kitagawa T, Baron B, Tokunaga M, Harada K, Terasaki M, Uehara O, Ohta T, Takai R, Hamada JI, Kobayashi M, Shimo T, Nagayasu H, Kuramitsu Y. (PubMed

Active hexose-correlated compound down-regulates HSP27 of pancreatic cancer cells, and helps the cytotoxic effect of gemcitabine. Suenaga S, Kuramitsu Y, Kaino S, Maehara S, Maehara Y, Sakaida I, Nakamura K. (PubMed

Ovarian Microbiota, Ovarian Cancer and the Underestimated Role of HPV. Cazzaniga M, Cardinali M, Di Pierro F, Bertuccioli A. (PubMed

Active hexose-correlated compound and Bifidobacterium longum BB536 exert symbiotic effects in experimental colitis. Ocón B, Anzola A, Ortega-González M, Zarzuelo A, Suárez MD, Sánchez de Medina F, Martínez-Augustin O. (PubMed

Active Hexose-correlated Compound Down-regulates Heat Shock Factor 1, a Transcription Factor for HSP27, in Gemcitabine-resistant Human Pancreatic Cancer Cells. Tokunaga M, Baron B, Kitagawa T, Tokuda K, Kuramitsu Y. (PubMed

Low-energy amplitude-modulated radiofrequency electromagnetic fields as a systemic treatment for cancer: Review and proposed mechanisms of action. Tuszynski JA, Costa F. (PubMed

Efficacy of Lentinula edodes Mycelia Extract on Chemotherapy-Related Tasted Disorders in Pancreatic Cancer Patients. Yanagimoto H, Hirooka S, Yamamoto T, Yamaki S, Sekimoto M. (PubMed

The use of mushroom glucans and proteoglycans in cancer treatment. Kidd PM. (PubMed

Effect of active hexose-correlated compound in women receiving adjuvant chemotherapy for breast cancer: a retrospective study. Hangai S, Iwase S, Kawaguchi T, Kogure Y, Miyaji T, Matsunaga T, Nagumo Y, Yamaguchi T. (PubMed

Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study. Matsui Y, Uhara J, Satoi S, Kaibori M, Yamada H, Kitade H, Imamura A, Takai S, Kawaguchi Y, Kwon AH, Kamiyama Y. (PubMed

Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents. Mach CM, Fugii H, Wakame K, Smith J. (PubMed

Effects of active hexose correlated compound on frequency of CD4+ and CD8+ T cells producing interferon-γ and/or tumor necrosis factor-α in healthy adults. Yin Z, Fujii H, Walshe T. (PubMed

Bioactive Immunomodulatory Compounds: A Novel Combinatorial Strategy for Integrated Medicine in Oncology? BAIC Exposure in Cancer Cells. Corradetti B, Vaiasicca S, Mantovani M, Virgili E, Bonucci M, Hammarberg Ferri I. (PubMed

Randomized, allopurinol-controlled trial of the effects of dietary nucleotides and active hexose correlated compound in the treatment of canine leishmaniosis. Segarra S, Miró G, Montoya A, Pardo-Marín L, Boqué N, Ferrer L, Cerón J. (PubMed

Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer. Turner J, Chaudhary U. (PubMed

← Back to Homepage